| Small Intestine | Large Intestine |
| Present of villi | No villi |
| Less Crypts of Lieberkuhn | More Crypts of Lieberkuhn |
| Less number of Goblet Cells | More Goblet cells |
| Present of Brunner’s gland in Submucosa of Duodenum | Brunner’s glands is absent |
| Taenia Coli is absent | Taenia Coli present at Muscularis Externa |
| Small intestine (except duodenum) is mobile | Ascending and descending parts of colon is fixed |
| Caliber of Small intestine is smaller | Caliber of Large intestine is larger |
| Present of mesentery that passes downward across midline into right iliac fossa | Absent of mesentry |
| The longitudinal muscle forms continuous layer around the gut | The longitudinal muscle is collected into three bands (taenia coli) |
| No fatty tags attach to the wall | Fatty tags (appendices epiploicae) attach to the wall |
| Wall of small intestine is smooth | Wall of large intestine is sacculated |
| Plicae circularis is permanent | Absent of Plicae circularis |
| Peyer patches found in mucous membrane | Peyer Patches is absent in mucous membrane |
| Mucous membrane contain villi | Absent of villi in mucous membrane |
